Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog.

@article{Rosseels2013HydroxypropylcyclodextrinIR,
  title={Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog.},
  author={Marie-Luce A Rosseels and A. Delaunois and Etienne Hanon and Philippe Guillaume and Fr{\'e}d{\'e}ric D C Martin and Diels J van den Dobbelsteen},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2013},
  volume={67 3},
  pages={351-9}
}
Hydroxypropyl-β-cyclodextrin (HPβCD) is a complexation agent used to enhance drug solubilization and formulation stability. Although its toxicity is well characterized, its cardiovascular effects are less known. To investigate them, HPβCD was infused intravenously over 10 min in anesthetized dogs (10-40% (w/v, i.e. 200-800 mg/kg) in non-denervated animals and at 40% in denervated animals). HPβCD increased renal arteriolar resistance and decreased renal blood flow at all doses, almost… CONTINUE READING