Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.

@article{Liu2000HydroxyprolylserineDJ,
  title={Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.},
  author={Kexin Liu and Yukio Kato and Tohru Kaku and Thomas Santa and Kozue Imai and Akira Yagi and Takashi Ishizu and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 2},
  pages={510-5}
}
It has been a desire to develop orally effective therapeutic agents that restore the liver function in chronic injury. Here we demonstrated that trans-4-L-hydroxyprolyl-L-serine (JBP923) and cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485), which was previously isolated from hydrolysate of human placenta, exhibit potent antihepatitis activity after their… CONTINUE READING