Hydroxyproline quantification for the estimation of collagen in tissue using multiple reaction monitoring mass spectrometry.

@article{Colgrave2008HydroxyprolineQF,
  title={Hydroxyproline quantification for the estimation of collagen in tissue using multiple reaction monitoring mass spectrometry.},
  author={Michelle L Colgrave and Peter G Allingham and Alun Jones},
  journal={Journal of chromatography. A},
  year={2008},
  volume={1212 1-2},
  pages={150-3}
}
Collagens are highly abundant mammalian proteins that contain a high content of hydroxylated amino acids such as hydroxyproline. We have exploited the high hydroxyproline content of collagen and developed a method for hydroxyproline quantification as a measure of collagen content in muscle samples. The novel method utilizes a highly selective and sensitive method of multiple reaction monitoring (MRM) by mass spectrometry. The analytical method is simple, rapid (5min), convenient (no… CONTINUE READING

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