Hydroxyoctadecadienoic Acids Regulate Apoptosis in Human THP-1 Cells in a PPARγ-Dependent Manner

@article{Vangaveti2014HydroxyoctadecadienoicAR,
  title={Hydroxyoctadecadienoic Acids Regulate Apoptosis in Human THP-1 Cells in a PPARγ-Dependent Manner},
  author={Venkat Vangaveti and Venkatesh M. Shashidhar and Catherine Rush and Usman H Malabu and Roy R. Rasalam and Fiona McL Collier and Bernhard T. Baune and Richard Lee Kennedy},
  journal={Lipids},
  year={2014},
  volume={49},
  pages={1181-1192}
}
Macrophage apoptosis, a key process in atherogenesis, is regulated by oxidation products, including hydroxyoctadecadienoic acids (HODEs). These stable oxidation products of linoleic acid (LA) are abundant in atherosclerotic plaque and activate PPARγ and GPR132. We investigated the mechanisms through which HODEs regulate apoptosis. The effect of HODEs on THP-1 monocytes and adherent THP-1 cells were compared with other C18 fatty acids, LA and α-linolenic acid (ALA). The number of cells was… CONTINUE READING
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