Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis

  title={Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis},
  author={Christos Hatzigeorgiou and Jeffrey L Jackson},
  journal={Osteoporosis International},
Studies determining the association between hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) and bone metabolism are mixed. We conducted a systematic review to assess the potential impact of statins on fractures, bone mineral density and bone markers. We searched Medline, Embase, the Cochrane Library, and Federal Research in Progress (FEDRIP). Inclusion criteria consisted of human studies with measurable outcomes, which were rated as good or fair according to the United… CONTINUE READING
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