Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

  title={Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations},
  author={Gunnar Alv{\'a}n and Paul Bechtel and Lennart Iselius and Ursula M. Gundert-Remy},
  journal={European Journal of Clinical Pharmacology},
European data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been collected. No significant difference in phenotype frequencies was found between the separate series for debrisoquine, sparteine and dextromethorphan, which supports the claim that these probe drugs reflect the same enzyme polymorphism. The mean frequency of the phenotype slow debrisoquine metaboliser was 7.65% based on 5005 determinations. The overall mean reflecting all three… CONTINUE READING


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