Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

@article{Rettie1992HydroxylationOW,
  title={Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.},
  author={A. Rettie and K. Korzekwa and K. Kunze and R. Lawrence and A. Eddy and T. Aoyama and H. Gelboin and F. Gonzalez and W. Trager},
  journal={Chemical research in toxicology},
  year={1992},
  volume={5 1},
  pages={
          54-9
        }
}
Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in human liver microsomes which appears to be responsible for the termination of warfarin's biological activity. Inhibition of the formation of (S)-7-hydroxywarfarin, the inactive, major metabolite of racemic warfarin in humans, is known to be the cause of several of the drug interactions experienced clinically upon coadministration of warfarin with other therapeutic agents. In order to identify the… Expand
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