Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.

@article{Liu2009HydroxylationOT,
  title={Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.},
  author={H Liu and Yin Chang Hu and Yong Hui Liu and Y He and Wenying Li and Ling Yang},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2009},
  volume={39 5},
  pages={382-90}
}
Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities. In the present study, the metabolism of tanshinone IIa (5 microM) by cytochrome P450s (CYPs) was investigated in human liver microsomes. One mono-hydroxylated metabolite was detected in a reaction catalysed by human liver microsomes, and was identified as tanshinone IIb by comparing the tandem mass spectra and the chromatographic retention… CONTINUE READING