Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype.

  title={Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype.},
  author={Edoardo Spina and Ernie Steiner and Orjan Ericsson and Folke Sj{\"o}qvist},
  journal={Clinical pharmacology and therapeutics},
  volume={41 3},
The 2-hydroxylation of desmethylimipramine (DMI) was studied in 14 healthy subjects previously phenotyped with respect to debrisoquin hydroxylation. After a single oral dose (25 mg), slow hydroxylators of debrisoquin had significantly lower total and metabolic clearances and longer plasma half-lives of DMI and excreted less 2-hydroxydesmethylimipramine than did rapid hydroxylators. These findings strengthen the hypothesis that the hydroxylations of debrisoquin and DMI may be under common… CONTINUE READING

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