Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype.

@article{Spina1987HydroxylationOD,
  title={Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype.},
  author={Edoardo Spina and Ernie Steiner and Orjan Ericsson and Folke Sj{\"o}qvist},
  journal={Clinical pharmacology and therapeutics},
  year={1987},
  volume={41 3},
  pages={314-9}
}
The 2-hydroxylation of desmethylimipramine (DMI) was studied in 14 healthy subjects previously phenotyped with respect to debrisoquin hydroxylation. After a single oral dose (25 mg), slow hydroxylators of debrisoquin had significantly lower total and metabolic clearances and longer plasma half-lives of DMI and excreted less 2-hydroxydesmethylimipramine than did rapid hydroxylators. These findings strengthen the hypothesis that the hydroxylations of debrisoquin and DMI may be under common… CONTINUE READING

From This Paper

Topics from this paper.
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…