Hydroxylation of demethoxy-Q 6 constitutes a control point in yeast coenzyme Q 6

@inproceedings{Padilla2009HydroxylationOD,
  title={Hydroxylation of demethoxy-Q 6 constitutes a control point in yeast coenzyme Q 6},
  author={Sergio Antonio Padilla Padilla and Uyenphuong C Tran and Mar{\'i}a A Jim{\'e}nez-Hidalgo and Jos{\'e} Mar{\'i}a L{\'o}pez-Mart{\'i}n and Alejandro Mart{\'i}n-Montalvo and Catherine F. Clarke and Placido Navas and Carlos Santos-Oca{\~n}a},
  year={2009}
}
Coenzyme Q is a lipid molecule required for respiration and antioxidant protection. Q biosynthesis in Saccharomyces cerevisiae requires nine proteins (Coq1p–Coq9p). We demonstrate in this study that Q levels are modulated during growth by its conversion from demethoxy-Q (DMQ), a late intermediate. Similar conversion was produced when cells were subjected to oxidative stress conditions. Changes in Q6/DMQ6 ratio were accompanied by changes in COQ7 gene mRNA levels encoding the protein responsible… CONTINUE READING

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