Hydroxylation of aromatic hydrocarbons in the rat.

  title={Hydroxylation of aromatic hydrocarbons in the rat.},
  author={Olav M. Bakke and Ronald R. Scheline},
  journal={Toxicology and applied pharmacology},
  volume={16 3},
Detection of Phenolic Metabolites of Styrene in Mouse Liver and Lung Microsomal Incubations
Pulmonary toxicity of 2- VP, 3-VP, and 4-VP was evaluated in CD-1 mice, and 5-phenyl-1-pentyne significantly inhibited the formation of the VPs and styrene glycol.
Effect of toluene and xylenes on liver glutathione and their urinary excretion as mercapturic acids in the rat
Results demonstrate the involvement of a thusfar unknown pathway in the biotransformation of toluene and xylenes and the reactivity of a metabolite of o-xylene, which is not formed during incubation with 105,000 g supernatant, reacts with glutathione.
Determination of Urinary Phenolic Metabolites from Rats Treated with 1,2,3‐ and 1,3,5‐ Trimethylbenzenes
Trimethylbenzene (TMB) is widely used as a solvent in the print and paint industries, and for products such as paint and varnish. Hence it causes environmental contamination not only in work places
Alcohol and sulphate intermediates in the metabolism of toluene and xylenes to mercapturic acids
The involvement of sequential side‐chain oxidation, sulphation and glutathione conjugation in the formation of mercapturic acids from toluene and xylenes was investigated. It was found that not only
Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat.
14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue, and tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine.
Relationship between hydrocarbon structure and induction of P450: effects on protein levels and enzyme activities.
A unique induction pattern observed after m-xylene treatment can be accounted for by induction of P 450 2B1/2B2 without concomitant suppression of P450 2C11, a pattern that was found when the metabolism of the substrate was catalysed by both theP450 2B subfamily and P4502C11.


Metabolism of benzene in nonfasted, fasted, and aryl-hydroxylase inhibited rats.
The effect of neomycin and experimental coprostasis on the excretion of simple phenols in the rat.
  • O. Bakke
  • Medicine
    Scandinavian journal of gastroenterology
  • 1969
Six simple phenols in acid-hydrolyzed rat urine have been analyzed by gas chromatography and a reduction of 96 per cent was observed in the excretion of phenol, p-cresol, and 4-ethylphenol following oral neomycin treatment.
Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents
  • R. Scheline
  • Chemistry, Biology
    The Journal of pharmacy and pharmacology
  • 1966
Rat caecal contents decarboxylate phenolic benzoic acid derivatives when a free hydroxyl group is in the para position but the presence of substituents adjacent to this group or the carboxyl group
Metabolism of phenolic acids by the rat intestinal microflora.
  • R. Scheline
  • Biology
    Acta pharmacologica et toxicologica
  • 1968