Hydroxylation of HIF-1: oxygen sensing at the molecular level.

@article{Semenza2004HydroxylationOH,
  title={Hydroxylation of HIF-1: oxygen sensing at the molecular level.},
  author={Gregg L Semenza},
  journal={Physiology},
  year={2004},
  volume={19},
  pages={
          176-82
        }
}
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression. 

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