Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger

@article{Parshikov2004HydroxylationO1,
  title={Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger},
  author={I. Parshikov and B. Miriyala and M. Avery and J. Williamson},
  journal={Biotechnology Letters},
  year={2004},
  volume={26},
  pages={607-610}
}
The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 °C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l−1) to 15-hydroxy-10-deoxoartemisinin (26%) and 7β-hydroxy-10-deoxoartemisinin (69%). 
15 Citations
Evaluation of Microbial Transformation of 10-deoxoartemisinin by UPLC-ESI-Q-TOF-MSE
Biotransformation of artemisinin by Aspergillus niger
Microbial transformation of antimalarial terpenoids.
Biotransformation of piceid in Polygonum cuspidatum to resveratrol by Aspergillus oryzae
...
1
2
...

References

SHOWING 1-6 OF 6 REFERENCES
Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.
Synthesis and antimalarial activity of (+)-deoxoartemisinin.
Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, Deoxoartemisinin
Microbial models of mammalian metabolism of xenobiotics: An updated review.