Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1.

@article{Liu2006HydroxylatedPB,
  title={Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1.},
  author={Yungang Liu and T Idil Apak and Hans-Joachim Lehmler and Larry W Robertson and Michael W. Duffel},
  journal={Chemical research in toxicology},
  year={2006},
  volume={19 11},
  pages={1420-5}
}
Polychlorinated biphenyls (PCBs) are important persistent environmental contaminants. PCBs can be metabolically converted to their hydroxylated metabolites (OHPCBs), and in recent years, these OHPCBs have been observed to inhibit human sulfotransferases (SULTs) such as the phenol SULTs (SULT family-1) involved in the metabolism of estrogen and various other endogenous and xenobiotic phenols. In the present study, we have investigated the hypothesis that OHPCBs interact with family 2… CONTINUE READING

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