Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].

Abstract

As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.

Statistics

050020072008200920102011201220132014201520162017
Citations per Year

270 Citations

Semantic Scholar estimates that this publication has 270 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bennett2006HydroxylatedAO, title={Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].}, author={Frank Bennett and Anil K. Saksena and Raymond G. Lovey and Yi-Tsung Liu and Naginbhai M Patel and Patrick Pinto and Russel E Pike and Edwin Jao and Viyyoor M. Girijavallabhan and Ashit K. Ganguly and David Loebenberg and Haiyan Wang and Anthony F. Cacciapuoti and Eugene Moss and Fred Menzel and Roberta S Hare and Amin A. Nomeir}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 1}, pages={186-90} }