Hydroxylamine moiety of developmental toxicants is associated with early cell death: a structure-activity analysis.

@article{Desesso2000HydroxylamineMO,
  title={Hydroxylamine moiety of developmental toxicants is associated with early cell death: a structure-activity analysis.},
  author={John M Desesso and Catherine F Jacobson and Anthony R Scialli and Gerald C. Goeringer},
  journal={Teratology},
  year={2000},
  volume={62 5},
  pages={346-55}
}
BACKGROUND Cellular debris, an indicator of cell death, appears in limb buds of gestational day 12 rabbit embryos 4 hr after either a subcutaneous injection of hydroxyurea to pregnant rabbits or an injection of hydroxyurea into the exocoelomic cavities of the embryos. This episode of early cell death appears to be central to the teratogenic action of hydroxyurea. Several chemicals that are structurally related to hydroxyurea, and that possess a terminal hydroxylamine moiety (-NHOH), also… CONTINUE READING