Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation: relationship to ethanol metabolism.

@article{McCay1992HydroxylRA,
  title={Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation: relationship to ethanol metabolism.},
  author={Paul B. McCay and Lester A. Reinke and J M Rau},
  journal={Free radical research communications},
  year={1992},
  volume={15 6},
  pages={335-46}
}
Ethanol is metabolized to acetaldehyde by hepatic microsomes in a reaction that requires cytochrome P-450, and a role for hydroxyl radicals has been implicated in this process. However, previous spin trapping experiments have failed to demonstrate the production of hydroxyl radicals by liver microsomes unless iron or other metal catalysts have been added. The spin trapping experiments described in this report provide unambiguous evidence that liver microsomes form hydroxyl radicals during… CONTINUE READING

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