Hydroxyl radical is the major causative factor in stress-induced gastric ulceration.

@article{Das1997HydroxylRI,
  title={Hydroxyl radical is the major causative factor in stress-induced gastric ulceration.},
  author={Dipak Kumar Das and Debashis Bandyopadhyay and Mrinalini Bhattacharjee and Ranajit K. Banerjee},
  journal={Free radical biology & medicine},
  year={1997},
  volume={23 1},
  pages={
          8-18
        }
}
The role of the metal-catalyzed production of hydroxyl radicals (OH.) on gastric ulceration caused by restraint-cold stress in rat was studied. Stress causes a 50% increase in the thiobarbituric acid reactive species (TBARS) as a measure of the lipid peroxidation, nearly 70% increase in protein oxidation as measured by its carbonyl content and about 40% decrease in the glutathione content of the fundic stomach, suggesting oxidative damage by stress. Stress also causes a time-dependent increase… CONTINUE READING
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