Hydroxyl radical formation via iron-mediated Fenton chemistry is inhibited by methylated catechols.

@article{Nappi1998HydroxylRF,
  title={Hydroxyl radical formation via iron-mediated Fenton chemistry is inhibited by methylated catechols.},
  author={Anthony Joseph Nappi and Emily Vass},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1425 1},
  pages={
          159-67
        }
}
The differing effects of O-methylated catecholamines and their dihydroxyphenyl precursors on the production of *OH were quantified using a previously established specific salicylate hydroxylation assay in conjunction with a sensitive electrochemical detection system. The production of *OH by the Fenton reaction was diminished significantly by O-methylated catecholamines (O-methyldopa, O-methyldopamine, O-methyltyrosine, and N-acetyl-O-methyldopamine), whereas radical production was augmented by… CONTINUE READING
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