Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides. Catalysis by hemoglobin and microsomes.

Abstract

Kinetic, circular dichroism, and NADH and NADPH fluorescence quenching studies indicate that these compounds interact with the antimalarial drug primaquine (PQ). The affinity of both pyridine nucleotides for PQ is similar. The data are in contrast with a previous report (Thornalley et al. (1983) Biochem. Pharmacol. 32, 3571-3575) suggesting specificity for… (More)

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Cite this paper

@article{Augusto1986HydroxylRF, title={Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides. Catalysis by hemoglobin and microsomes.}, author={O. B. Augusto and C L Weingrill and Spencer John Schreier and Hidetake Amemiya}, journal={Archives of biochemistry and biophysics}, year={1986}, volume={244 1}, pages={147-55} }