Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583.

@article{Kontos1993HydroxylRI,
  title={Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583.},
  author={Hermes A. Kontos and Enoch P. Wei},
  journal={Stroke},
  year={1993},
  volume={24 3},
  pages={427-34}
}
BACKGROUND AND PURPOSE Methylene blue and 6-anilino,5,8-quinolinedione (LY83583) are used extensively to block activation of guanylate cyclase. Both agents generate oxygen radicals. Therefore, it appeared profitable to investigate whether the generation of oxygen radicals by these agents is responsible for the blockade of responses to nitrodilators that act via activation of guanylate cyclase to relax vascular smooth muscle and cause vasodilation. METHODS We tested in anesthetized cats… CONTINUE READING
30 Citations
24 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Inhibition by LY 83583 of endothelium - dependent relaxation of rabbit aorta

  • AS Gidari, RF Furchgott, D Jothinandan
  • ( abstract ) FASEB J
  • 1989

Similar Papers

Loading similar papers…