Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups

@inproceedings{Wang2015HydroxylcontainingNL,
  title={Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups},
  author={Hai-Jiao Wang and Xi Qin He and Yang Zhang and Ji Zhang and Yan-hong Liu and Xiaoqi Yu},
  year={2015}
}
Cationic lipids are the most widely used non-viral gene vectors, and it is important to develop novel lipids that have high transfection efficiency (TE) and good biocompatibility. A series of macrocyclic polyamine (cyclen and TACN)-based cationic lipids bearing different hydrophobic tails were synthesized with the ring-opening reaction. Several assays were used to study their interactions with plasmid DNA, and these lipoplexes could efficiently condense DNA into nanoparticles with proper sizes… CONTINUE READING

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