Hydroxyl-Directed Stereoselective Diboration of Alkenes


An alkoxide-catalyzed directed diboration of alkenyl alcohols is described. This reaction occurs in a stereoselective fashion and is demonstrated with cyclic and acyclic homoallylic and bishomoallylic alcohol substrates. After oxidation, the reaction generates 1,2-diols such that the process represents a method for the stereoselective directed dihydroxylation of alkenes.

DOI: 10.1021/ja504228p

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@inproceedings{Blaisdell2014HydroxylDirectedSD, title={Hydroxyl-Directed Stereoselective Diboration of Alkenes}, author={Thomas P. Blaisdell and Thomas C. Caya and Liang Zhang and Amparo Sanz-Marco and James P Morken}, booktitle={Journal of the American Chemical Society}, year={2014} }