Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsis.

@article{Shatney1984HydroxyethylstarchAD,
  title={Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsis.},
  author={Clayton H Shatney and Irshad H. Chaudry},
  journal={Circulatory shock},
  year={1984},
  volume={13 1},
  pages={21-6}
}
Hydroxyethylstarch (HES) is being used increasingly in clinical hemorrhagic shock. Since patients in shock are at high risk of subsequent infection, concern has been voiced about possible adverse effects of HES on the reticuloendothelial system (RES) and host defenses against sepsis. We examined this issue in male albino Holtzman rats given HES or saline (60 ml/kg) i.v. RES function was evaluated 24 and 48 h after HES administration by measuring the intravascular clearance rates (t/2) and organ… CONTINUE READING

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