Hydroxyethylated cationic cholesterol derivatives in liposome vectors promote gene expression in the lung.

@article{Ding2008HydroxyethylatedCC,
  title={Hydroxyethylated cationic cholesterol derivatives in liposome vectors promote gene expression in the lung.},
  author={Wuxiao Ding and Yoshiyuki Hattori and Kimio Higashiyama and Yoshie Maitani},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={354 1-2},
  pages={196-203}
}
Three cationic cholesterol derivatives (CCDs), which differ in their types of amine and bear a hydroxyethyl group at the amine group, were synthesized and formulated into liposomes and nanoparticles as gene delivery vectors. In vitro transfection into A549 cells proved that liposomes formulated with CCDs and dioleoylphosphatidylethanolamine (DOPE) of 1/2 molar ratio were more effective than the corresponding nanoparticles with CCDs and Tween 80 at charge ratios (+/-) of 1/2, 3/1 and 5/1. Among… CONTINUE READING