Hydroxychloroquine decreases human MSC‐derived osteoblast differentiation and mineralization in vitro

@inproceedings{Both2018HydroxychloroquineDH,
  title={Hydroxychloroquine decreases human MSC‐derived osteoblast differentiation and mineralization in vitro
},
  author={Tim Both and H. Jeroen van de Peppel and M C Carola Zillikens and Marijke Koedam and Johannes P T M van Leeuwen and P. Martin van Hagen and Paul L. A. van Daele and Bram C. J. van der Eerden},
  booktitle={Journal of cellular and molecular medicine},
  year={2018}
}
We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) compared to healthy controls. The majority of those patients (69%) was using hydroxychloroquine (HCQ), which may have favourable effects on BMD. To study the direct effects of HCQ on human MSC-derived osteoblast activity. Osteoblasts were cultured from human mesenchymal stromal cells (hMSCs). Cultures were treated with different HCQ doses (control, 1 and 5 µg/ml). Alkaline… CONTINUE READING