Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle

@article{Murata2009HydroxychavicolAP,
  title={Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle},
  author={Kazuya Murata and Kikuyo Nakao and Noriko Hirata and K Namba and Takao Nomi and Yoshihisa Kitamura and Kenzo Moriyama and Takahiro Shintani and Munekazu Iinuma and Hideaki Matsuda},
  journal={Journal of Natural Medicines},
  year={2009},
  volume={63},
  pages={355-359}
}
The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia. 
Xanthine oxidase inhibitory properties of Czech medicinal plants.
TLDR
Populus nigra and Betula pendula were identified as species with the highest xanthine oxidase inhibitory potential in this study, which correlates with the ethnobotanical data on their use in Central European folklore and provides the basis for further investigation on these plants.
Bioactive Natural Products from Piper betle L. Leaves and their α- Glucosidase Inhibitory Potential
Piper betle L. can be a valuable proposal for the prevention and treatment of several disorders. In fact, its leaves are largely consumed as mouth freshener and masticator, being known for their
Comparative evaluation of xanthine oxidase inhibitory activity of Allium ceba L., Azadirachta indica A.Juss. and Piper betle L. extracts alone and in combination
The present study was conducted to assess the xanthine oxidase inhibitory activity of Allium ceba L., Azadirachta indica A.Juss. and Piper betle L. alone and in combination, using double beam visible
Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha.
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Hydroxychavicol is reported to possess anti-carcinogenic, anti-oxidant,Anti-microbial and anti-inflammatory activity which is related to traditional usage of this plant, which offers this plant as an attractive material for treating various health problems including obesity.
Xanthine oxidase inhibitors isolated from Piper nudibaccatum
Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by
Improving the knowledge on Piper betle: targeted metabolite analysis and effect on acetylcholinesterase.
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Piper betle is a species growing in South East Asia, where its leaves are economically and medicinally important, and its leaves were subjected to headspace solid-phase microextraction, hydrodistillation and Soxhlet extraction, prior to analysis by GC/MS.
Inhibitory effect of verbascoside on xanthine oxidase activity.
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The results suggested that verbascoside, which is a naturally occurring water-soluble antioxidant, could be a potential low-toxicity XOD inhibitor for hyperuricemia treatment.
Phytochemical composition, β-glucuronidase inhibition, and antioxidant properties of two fractions of Piper betle leaf aqueous extract.
TLDR
Phytochemical composition of two solvent fractions of the aqueous extracts obtained from eight varieties of P. betle leaves were analyzed to validate some medicinal properties of the said leaves and identified the active components against β-glucuronidase by chemometric analysis.
Piper betle Linn. a maligned Pan-asiatic plant with an array of pharmacological activities and prospects for drug discovery
TLDR
A number of biologically active compounds from P. betle have potential for use as medicines, neutraceuticals and industrial compounds, including anti-inflammatory, anti-cancer and immunomodulatory activities.
Bio‐actives of betel leaf (Piper betle L.): A comprehensive review on extraction, isolation, characterization, and biological activity
TLDR
The present review provides information on extraction techniques, identification of bioactive compounds, and their biological activities, and information on processing, preservation, and health benefits along with their mechanisms has been added.
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