Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders.

  title={Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders.},
  author={Jerry L. Spivak and Hans K Hasselbalch},
  journal={Expert review of anticancer therapy},
  volume={11 3},
Hydroxycarbamide is a nonalkylating antiproliferative and antiviral agent that has been used for over 40 years to treat a variety of neoplastic and non-neoplastic conditions. Hydroxycarbamide is readily absorbed and widely distributed throughout the body. It acts primarily to inhibit DNA synthesis, which underpins its use in solid tumors, viral infections and chronic myeloproliferative disorders. Hydroxycarbamide is an effective treatment for preventing transient ischemic attacks associated… CONTINUE READING