Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo.

@article{Guo2017HydroxycamptothecinNP,
  title={Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo.},
  author={Yifei Guo and Yanna Zhao and Ting Wang and Ran Li and Xiangtao Wang and Zhengqi Dong and Chunyan Zhu},
  journal={Bioconjugate chemistry},
  year={2017},
  volume={28 2},
  pages={
          390-399
        }
}
Nanorods based on dendrimers were explored as excellent candidates for nanoscale drug delivery system. In this study, fluorescently labeled PAMAM-b-oligoethylene glycols codendrimer (POC) was utilized as carrier to prepare 10-hydroxycamptothecin (HCPT) loaded nanorods (HCPT NRs) via antisolvent precipitation method augmented by ultrasonication with the optimized drug-loading content (∼90.6%) and positive charged surface. The nanorods presented high stability, and the release of HCPT nanorods… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS

Effect of alkyl chain on cellular uptake and antitumor activity of hydroxycamptothecin nanoparticles based on amphiphilic linear molecules.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2019