Hydroxyapatite induces autolytic degradation and inactivation of matrix metalloproteinase-1 and -3.

@article{Kremer1998HydroxyapatiteIA,
  title={Hydroxyapatite induces autolytic degradation and inactivation of matrix metalloproteinase-1 and -3.},
  author={E A Kremer and Y Chen and Kazuharu Suzuki and Hideaki Nagase and Jeffrey Paul Gorski},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1998},
  volume={13 12},
  pages={1890-902}
}
In the course of studies to identify a protease capable of producing a long-lived 50 kDa fragment of bone acidic glycoprotein-75 (BAG-75), it was observed that incubation of matrix metalloproteinase (MMP)-3 (stromelysin 1) with preparations of BAG-75 led to inactivation of proteolytic function, e.g., an inability to fragment 125I-labeled BAG-75 added subsequently. MMP-1 (interstitial collagenase) was also inactivated by exposure to BAG-75 preparations. Investigation of the mechanism revealed… CONTINUE READING

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