Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity.

@article{Ciocilteu2018HydroxyapatiteciprofloxacinDS,
  title={Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity.},
  author={Maria-Viorica Ciocilteu and Andreea Gabriela Mocanu and Adriana Mocanu and Cătălin Ducu and Oana Elena Nicolaescu and Valentin Costel Manda and Adina Turcu-Stiolica and Claudiu Nicolicescu and Razvan Petru Melinte and Maria Bălăşoiu and Octavian Croitoru and Johny Neamţu},
  journal={Acta pharmaceutica},
  year={2018},
  volume={68 2},
  pages={
          129-144
        }
}
The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger… CONTINUE READING
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