Hydroxocobalamin and epinephrine both improve survival in a swine model of cyanide-induced cardiac arrest.

@article{Bebarta2012HydroxocobalaminAE,
  title={Hydroxocobalamin and epinephrine both improve survival in a swine model of cyanide-induced cardiac arrest.},
  author={Vikhyat S Bebarta and Rebecca L Pitotti and Patricia S Dixon and Sandra Valtier and Luis Esquivel and Anneke C Bush and Charles M Little},
  journal={Annals of emergency medicine},
  year={2012},
  volume={60 4},
  pages={415-22}
}
STUDY OBJECTIVE To determine whether hydroxocobalamin will improve survival compared with epinephrine and saline solution controls in a model of cyanide-induced cardiac arrest. METHODS Forty-five swine (38 to 42 kg) were tracheally intubated, anesthetized, and central venous and arterial continuous cardiovascular monitoring catheters were inserted. Potassium cyanide was infused until cardiac arrest developed, defined as mean arterial pressure less than 30 mm Hg. Animals were treated with… CONTINUE READING
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