Hydroxocobalamin administration for treatment of vasoplegic syndrome associated with cardiopulmonary bypass causes red plasma

@article{Saifee2019HydroxocobalaminAF,
  title={Hydroxocobalamin administration for treatment of vasoplegic syndrome associated with cardiopulmonary bypass causes red plasma},
  author={Nabiha Huq Saifee and Serena Sedgwick and Yanyun Wu},
  journal={Transfusion},
  year={2019},
  volume={60}
}
A 64-year-old female underwent cardiopulmonary bypass (CPB) for acute ST-elevation myocardial infarction and received a 5 g dose of intravenous hydroxocobalamin (Cyanokit, Meridian Medical Technologies) for treatment of vasoplegic syndrome. Figure 1 shows discolored plasma from a sample received for type and screen testing after surgery. The sample was initially rejected in the Transfusion Service, but discussion with the clinical team revealed that the discoloration was expected due to the… 

Hydroxocobalamin mimicking intravascular hemolysis in therapeutic plasma exchange

A 58-year-old man developed cardiogenic shock 12 months after undergoing orthotopic heart transplant and mixed antibodyand cellular-mediated rejection was diagnosed, and hydroxocobalamin 5000 mg had been administered intravenously approximately 24 hours previously to treat vasoplegic syndrome.

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