Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures

@inproceedings{Rieder2018HydrostaticPR,
  title={Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures},
  author={Bernhard Rieder and Anna Maria Weihs and Adelheid Weidinger and Dorota Szwarc and Sylvia N{\"u}rnberger and Heinz Redl and Dominik Ruenzler and Carina Huber-Gries and Andreas H Teuschl},
  booktitle={Scientific Reports},
  year={2018}
}
Osteoarthritis (OA) is one of the most common causes of disability and represents a major socio-economic burden. Despite intensive research, the molecular mechanisms responsible for the initiation and progression of OA remain inconclusive. In recent years experimental findings revealed elevated levels of reactive oxygen species (ROS) as a major factor contributing to the onset and progression of OA. Hence, we designed a hydrostatic pressure bioreactor system that is capable of stimulating… CONTINUE READING
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