Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

@article{Stewart2011HydrostaticPA,
  title={Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding},
  author={Martin P Stewart and J. Helenius and Y. Toyoda and Subramanian P. Ramanathan and Daniel J. Muller and A. Hyman},
  journal={Nature},
  year={2011},
  volume={469},
  pages={226-230}
}
During mitosis, adherent animal cells undergo a drastic shape change, from essentially flat to round. Mitotic cell rounding is thought to facilitate organization within the mitotic cell and be necessary for the geometric requirements of division. However, the forces that drive this shape change remain poorly understood in the presence of external impediments, such as a tissue environment. Here we use cantilevers to track cell rounding force and volume. We show that cells have an outward… Expand
476 Citations
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