Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium(v) catecholate complexes.

@article{Crans2019HydrophobicityME,
  title={Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium(v) catecholate complexes.},
  author={Debbie C Crans and Jordan T Koehn and Stephanie M Petry and Caleb M Glover and Asanka Wijetunga and Ravinder Kaur and Aviva Levina and Peter A Lay},
  journal={Dalton transactions},
  year={2019},
  volume={48 19},
  pages={
          6383-6395
        }
}
  • Debbie C Crans, Jordan T Koehn, +5 authors Peter A Lay
  • Published in Dalton transactions 2019
  • Chemistry, Medicine
  • Anti-cancer activities of vanadium compounds have generated recent interest because of a combination of desirable properties for chemotherapy, i.e., strong cytotoxicities, anti-metastatic activities and relatively low systemic toxicities. Certain hydrophobic vanadium(v) Schiff base/catecholate compounds, which as shown herein, have increased stability in aqueous media and affinity for membrane interfaces. Depending on their hydrophobicity, they may be able to enter cells intact. In this… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    1
    Twitter Mention