Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.

@article{Lopez1991HydrophobicSM,
  title={Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.},
  author={George A. Lopez and Yuh-Nung Jan and Lily Yeh Jan},
  journal={Neuron},
  year={1991},
  volume={7 2},
  pages={327-36}
}
Voltage-activated Na+, Ca2+, and K+ channels contain a common motif, the S4 sequence, characterized by a basic residue at every third position interspersed mainly with hydrophobic residues. The S4 sequence is proposed to function as the voltage sensor and to move in response to membrane depolarization, triggering conformational changes that open the channel. This hypothesis has been tested in previous studies which revealed that mutations of the S4 basic residues often shift the curve of… CONTINUE READING

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