Hydrophobic sequences target and anchor perilipin A to lipid droplets.

@article{Subramanian2004HydrophobicST,
  title={Hydrophobic sequences target and anchor perilipin A to lipid droplets.},
  author={Vidya Subramanian and A. Mejia Garcia and Anna Sekowski and Dawn L. Brasaemle},
  journal={Journal of lipid research},
  year={2004},
  volume={45 11},
  pages={
          1983-91
        }
}
Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic sequences (H1, H2, and H3) and an acidic region, targets and anchors perilipins to lipid droplets. Thus, we hypothesized that H1, H2, and H3 are targeting and anchoring motifs. We now show that deletion of any single hydrophobic sequence or combinations of H1 and H3 or H2 and H3 does not prevent targeting of the mutated perilipin to lipid droplets… CONTINUE READING

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