Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.

Abstract

One facet of cytokine signaling is relayed to the nucleus by the activation, through tyrosine phosphorylation, of latent cytoplasmic signal transducers and activators of transcription (STAT) family members. It has been demonstrated that the C termini of STATs contain the transactivation domain and are essential for the transactivation of target genes. To… (More)

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