Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

@article{Haldar2007HydrophobicPC,
  title={Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses},
  author={Jayanta Haldar and Jianzhu Chen and Terrence M. Tumpey and Larisa V Gubareva and Alexander M. Klibanov},
  journal={Biotechnology Letters},
  year={2007},
  volume={30},
  pages={475-479}
}
Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs. 
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Painting a glass slide with branched or linear N,N-dodecyl methyl-polyethylenimines and certain other hydrophobic PEI derivatives enables it to kill influenza virus within minutes, as well as the airborne human pathogenic bacteria Escherichia coli and Staphylococcus aureus.
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Protocols for the synthesis of the microbicidal polycation N,N-dodecyl,methyl-polyethylenimine and coating (painting) of glass slides with this polycation's butanol solution are described and procedures for validating that the resultant coated slides are essentially 100% lethal to human bacterial pathogens are detailed.
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