Hydrophobic membrane interaction of etidocaine, bupivacaine and 2-chloroprocaine

Abstract

It has been suggested that local anesthetics may block sodium conductance through nervous membranes also by hydrophobic interaction, e.g., by expanding the membrane. Decreased anisotropy (fluidization) and depressed phase transition temperatures have been shown by relatively high local anesthetic concentrations. We studied the dose dependence of the effect… (More)
DOI: 10.1007/BF00503919

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