Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy.

@article{Jiang2015HydrophobicIE,
  title={Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy.},
  author={Chenxiao Jiang and Hao Cheng and Ahu Yuan and Xiaolei Tang and Jinhui Wu and Yiqiao Hu},
  journal={Acta biomaterialia},
  year={2015},
  volume={14},
  pages={61-9}
}
It has been reported that IR780 iodide, a near-infrared dye, can be applied for cancer imaging, photodynamic therapy (PDT) and photothermal therapy (PTT). However, the hydrophobicity and toxicity of IR780 severely limit its further clinical applications. In this study, human serum albumin was used to load IR780 to form nanoparticles (HSA-IR780 NPs) by protein self-assembly. Compared to free IR-780, the solubility of HSA-IR780 NPs was greatly increased (1000-fold) while the toxicity was… CONTINUE READING
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