Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter

@article{Sviridov2013HydrophobicAA,
  title={Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter},
  author={Denis O. Sviridov and Alexander M. Andrianov and Ivan V. Anishchenko and John A. Stonik and Marcelo J A Amar and Scott M. Turner and Alan T. Remaley},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={344},
  pages={50 - 58}
}
The bihelical apolipoprotein mimetic peptide 5A effluxes cholesterol from cells and reduces inflammation and atherosclerosis in animal models. We investigated how hydrophobic residues in the hinge region between the two helices are important in the structure and function of this peptide. By simulated annealing analysis and molecular dynamics modeling, two hydrophobic amino acids, F-18 and W-21, in the hinge region were predicted to be relatively surface-exposed and to interact with the aqueous… Expand
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