Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer.

@article{Narayanasamy2006HydrophilicallyE3,
  title={Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer.},
  author={Sureshbabu Narayanasamy and B T S Thirumamagal and Jayaseharan Johnsamuel and Youngjoo Byun and A S Ashraf S Al-Madhoun and Elena Usova and Guirec Y Cosquer and Junhua Yan and Achintya K Bandyopadhyaya and Rohit Tiwari and Staffan Eriksson and Werner Tjarks},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 20},
  pages={6886-99}
}
Five novel 3-carboranyl thymidine analogues (3CTAs) were designed and synthesized for boron neutron capture therapy (BNCT) of cancer. Phosphorylation of all five 3CTAs was catalyzed by recombinant human thymidine kinase (hTK1) using adenosine triphosphate (ATP) as the phosphate donor. The obtained phosphorylation rates ranged from 4% to 64.5% relative to… CONTINUE READING