Hydrophilic poly(DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells.

@article{Walter2001HydrophilicPM,
  title={Hydrophilic poly(DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells.},
  author={Elke Walter and Donatus S Dreher and M Kok and L. Thiele and Stephen Gitahi Kiama and Peter Gehr and Hans Peter Merkle},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={76 1-2},
  pages={149-68}
}
Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have a proven track record for drug delivery and are suggested to be ideal carrier systems to target therapeutics into phagocytic cells such as macrophages (MPhis) and dendritic cells (DCs). Microspheres prepared by spray-drying from different PLGA-type polymers were evaluated regarding their effect on phagocytosis, intracellular degradation and viability of human-derived macrophages MPhis and DCs. Even the microspheres prepared from… CONTINUE READING

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