Hydrophilic interaction liquid chromatography coupled to electrospray mass spectrometry of small polar compounds in food analysis.

@article{SchlichtherleCerny2003HydrophilicIL,
  title={Hydrophilic interaction liquid chromatography coupled to electrospray mass spectrometry of small polar compounds in food analysis.},
  author={Hedwig Schlichtherle-Cerny and Michael Affolter and Christoph Cerny},
  journal={Analytical chemistry},
  year={2003},
  volume={75 10},
  pages={2349-54}
}
Reversed-phase liquid chromatography (RPLC) is commonly used to analyze nonvolatile components in food. However, polar low-molecular-weight compounds such as hydrophilic amino acids, di- and tripeptides, and organic acids are often not sufficiently retained and represent a challenge for RPLC. Hydrophilic interaction liquid chromatography in combination with electrospray mass spectrometry (HILIC-ESI-MS) on a carbamoyl-derivatized stationary phase was successfully employed to separate free amino… CONTINUE READING

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