Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2.

@article{Jabrek2004HydroperoxyFA,
  title={Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2.},
  author={Martin Jabůrek and Sayuri Miyamoto and Paolo Di Mascio and Keith D. Garlid and Petr Je{\vz}ek},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 51},
  pages={
          53097-102
        }
}
Functional activation of mitochondrial uncoupling protein-2 (UCP2) is proposed to decrease reactive oxygen species production. Skulachev and Goglia (Skulachev, V. P., and Goglia, F. (2003) FASEB J. 17, 1585-1591) hypothesized that hydroperoxy fatty acid anions are translocated by UCPs but cannot flip-flop across the membrane. We found that the second aspect is otherwise; the addition of synthesized linoleic acid hydroperoxides (LAOOH, a mix of four isomers) caused a fast flip-flop-dependent… CONTINUE READING

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