Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread.

@article{Lin2011HydrolyzableT,
  title={Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread.},
  author={Liang-Tzung Lin and Ting-Ying Chen and Chueh-Yao Chung and Ryan S. Noyce and T. Bruce Grindley and Craig McCormick and T. Lin and G F Wang and Chun-Ching Lin and Christopher D. Richardson},
  journal={Journal of virology},
  year={2011},
  volume={85 9},
  pages={4386-98}
}
Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that chebulagic acid (CHLA) and punicalagin (PUG), two hydrolyzable tannins isolated from the dried fruits of Terminalia chebula Retz. (Combretaceae), inhibit HSV-1 entry at… CONTINUE READING
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