Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.

@article{Uchida2010HydrolyticPP,
  title={Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.},
  author={Yoshikazu Uchida and Evi Houben and Kyungho Park and Sounthala Douangpanya and Yong-Moon Lee and Bill X. Wu and Yusuf A. Hannun and N. S. Radin and Peter M Elias and Walter M. Holleran},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 10},
  pages={
          2472-80
        }
}
Although ceramides (Cers) are key constituents of the epidermal permeability barrier, they also function as apoptogenic signals for UVB irradiation-induced apoptosis in epidermal keratinocytes. As epidermis is continuously exposed to UV irradiation, we hypothesized that Cer hydrolysis protects keratinocytes from UVB-induced apoptosis by attenuating Cer levels. Both low-dose UVB (L-UVB) (< 35 mJ cm(-2)) and high-dose UVB (H-UVB) (> or = 45 mJ cm(-2)) irradiation inhibited DNA synthesis in… CONTINUE READING

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