Hydrolytic enzyme production by Clostridium difficile and its relationship to toxin production and virulence in the hamster model.

@article{Seddon1990HydrolyticEP,
  title={Hydrolytic enzyme production by Clostridium difficile and its relationship to toxin production and virulence in the hamster model.},
  author={S V Seddon and I H Hemingway and S Peter Borriello},
  journal={Journal of medical microbiology},
  year={1990},
  volume={31 3},
  pages={169-74}
}
Thirty isolates of Clostridium difficile expressing different degrees of toxigenicity and virulence in an animal model were assayed for the production of chondroitin-4-sulphatase, hyaluronidase, heparinase, collagenase and protease. All strains demonstrated some hydrolytic enzyme activity. There was no direct correlation between toxigenic status, or virulence, and hydrolytic enzyme production. However, all five strains known to be highly virulent in the hamster model had hyaluronidase… CONTINUE READING